Overview of the Glymphatic System The glymphatic system, identified approximately a decade ago, functions as the central nervous system's waste management infrastructure. It integrates astroglial cells with perivascular pathways to mediate the convective flow of cerebrospinal fluid (CSF) into brain parenchyma, thereby expelling soluble proteins, metabolites, and toxicants. Distinct from the peripheral lymphatic system, the glymphatic network is uniquely adapted to the brain's

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